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Cancer burden in regard to homeostasis and the disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm “Epistemology of the origin of cancer”. Explanation numbers: A tumor nodule is reported to be first detectable by X-ray imaging when it has 107 cells  which was earlier 108 cells . The average number of cells in a tumor when it is first palpable was reported to be 109 cells in 2002  which approximately accounts for a tumor with 1g . As it was also reported to be 106 cells in 1943 , we decided to decrease this number for the illustration by 1 log only to 108 cells.