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Research Article

Table 2.

Summary and analysis of clinical signs of Sarcoptes scabiei var. canis naturally infested dogs administered either NexGard® or NexGard Spectra® per label instructions twice, one month apart (Visit 1 and Visit 2).

Clinical sign and score Number of dogs per score/Number of dogs examined
Visit 1, baseline (pre-treatment) Visit 2, one month after Visit 1 Visit 3, one month after Visit 2
Pruritus
NexGard ®
 No scratching 0/38 34/38 37/38
 Occasional scratching 10/38 4/38 1/38
 Constant scratching 28/38 0/38 0/38
  p-value (Generalized McNemar test) 0.0001 0.0001
NexGard Spectra ®
 No scratching 0/27 24/27 26/27
 Occasional scratching 8/27 3/27 1/27
 Constant scratching 19/27 0/27 0/27
  p-value (Generalized McNemar test) 0.0001 0.0001
Papules and crusts
NexGard ®
 No papules or crusts 0/38 31/38 36/38
 Occasional papules or crusts 8/38 6/38 2/38
 Numerous papules or crusts 30/38 1/38 0/38
  p-value (Generalized McNemar test) 0.0001 0.0001
NexGard Spectra ®
 No papules or crusts 0/27 18/27 25/27
 Occasional papules or crusts 7/27 9/27 2/27
 Numerous papules or crusts 20/27 0/27 0/27
  p-value (Generalized McNemar test) 0.0001 0.0001
Alopecia
NexGard ®
No alopecia (hair re-growth) 0/38 21/38 30/38
Areas with alopecia with partial hair (re-)growth 6/38 17/38 8/38
Areas with alopecia with no hair re-growth 32/38 0/38 0/38
 p-value (Generalized McNemar test) 0.0001 0.0001
NexGard Spectra ®
No alopecia (hair re-growth) 0/27 9/27 20/27
Areas with alopecia with partial hair (re-)growth 3/27 17/27 7/27
Areas with alopecia with no hair re-growth 24/27 1/27 0/27
 p-value (Generalized McNemar test) 0.0001 0.0001